Everything about N-acetylglucosamine totally explained
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N-Acetylglucosamine (
N-Acetyl-D-Glucosamine, or
GlcNAc, or
NAG) is a
monosaccharide derivative of
glucose. Chemically it's an amide between
glucosamine and
acetic acid. It has a molecular formula of
C8H15NO6, a
molar mass of 221.21 g/mol, and it's significant in several biological systems.
It is part of a biopolymer in the bacterial
cell wall, built from alternating units of GlcNAc and
N-acetylmuramic acid (MurNAc), cross-linked with
oligopeptides at the
lactic acid residue of MurNAc. This layered structure is called
peptidoglycan.
GlcNAc is the monomeric unit of the polymer
chitin, which forms the outer coverings of
insects and
crustaceans. GlcNAc is also of note in
neurotransmission, where it's thought to be an atypical
neurotransmitter functioning in nocioceptive (
pain) pathways.
It has been proposed as a treatment for
autoimmune diseases.
Further Information
Get more info on 'N-acetylglucosamine'.
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